Antiretroviral therapy, interferon sensitivity, and virologic setpoint in human immunodeficiency virus/hepatitis C virus coinfected patients

@article{Balagopal2014AntiretroviralTI,
  title={Antiretroviral therapy, interferon sensitivity, and virologic setpoint in human immunodeficiency virus/hepatitis C virus coinfected patients},
  author={Ashwin Balagopal and Abraham J. Kandathil and Yvonne Higgins and John J. Wood and Justin Richer and Jeffrey Quinn and Lois Eldred and Zhiping Li and Stuart C. Ray and Mark S. Sulkowski and David L. Thomas},
  journal={Hepatology},
  year={2014},
  volume={60}
}
Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) cause substantial mortality, especially in persons chronically infected with both viruses. HIV infection raises plasma HCV RNA levels and diminishes the response to exogenous alpha interferon (IFN). The degree to which antiretroviral therapy (ART) control of infection overcomes these HIV effects is unknown. Participants with HIV‐HCV coinfection were enrolled in a trial to measure HCV viral kinetics after IFN administration (ΔHCVIFN… 
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References

SHOWING 1-10 OF 50 REFERENCES
Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) dynamics during HCV treatment in HCV/HIV coinfection.
TLDR
Although the early viral kinetics of coinfected subjects treated with PEG-IFN or IFN differ from those of singly infected subjects, the treatment response seems unaffected and suggests that coinfection may contribute to a slower clearance of HCV.
Viral kinetics in hepatitis C or hepatitis C/human immunodeficiency virus-infected patients.
TLDR
Modeling with pooled parameters suggests baseline viral load is a key factor in time to response in this cohort of HCV/HIV-co-infected patients and efficiency was associated significantly with viral clearance.
Changes in Hepatitis C Viral Response After Initiation of Highly Active Antiretroviral Therapy and Control of HIV Viremia in Chronically Co-infected Individuals
TLDR
Control of HIV viremia may result in an early increase in HCV viresmia, and for every 1 log decrease of HIV VL there was a 0.14 log increase of HCV VL, indicating the exact mechanism of this flare seen with control of HIVviremia is unknown.
Changes in hepatitis C viral response after initiation of highly active antiretroviral therapy and control of HIV viremia in chronically co-infected individuals.
TLDR
Controlling HIV infection with highly active antiretroviral therapy (HAART) alone was not able to eliminate or significantly reduce the HCV viremia in this cohort of co-infected patients.
Cellular immune responses to HCV core increase and HCV RNA levels decrease during successful antiretroviral therapy
TLDR
Successful cART is associated with increasing cellular immune responses to HCV core peptides and with a slight long-term decrease in HCV RNA levels, in line with the favourable clinical effects of cART on the natural history of hepatitis C and with the current recommendation to start cART earlier in HCVs coinfected individuals.
Liver injury and changes in hepatitis C Virus (HCV) RNA load associated with protease inhibitor-based antiretroviral therapy for treatment-naive HCV-HIV-coinfected patients: lopinavir-ritonavir versus nelfinavir.
  • K. Sherman, N. Shire, B. D. da Silva
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
TLDR
A low baseline CD4+ cell count is associated with persistent increases in the HCV RNA load in nelfinavir-treated patients, and results warrant careful interpretation of abnormalities in the ALT load after HAART initiation in HCV-HIV-coinfected patients to prevent premature discontinuation of treatment.
Changes in Hepatitis C Virus (HCV) Viral Load and Interferon-&agr; Levels in HIV/HCV-Coinfected Patients Treated With Highly Active Antiretroviral Therapy
TLDR
In patients with baseline HIV titer >10,000 copies/mL, suppression of HIV replication by HAART was associated with an increase in HCV titer and a decrease in endogenous IFN-&agr; levels.
Effect of human immunodeficiency virus on hepatitis C virus infection among injecting drug users.
TLDR
While HIV infection and possibly HIV progression are associated with increased HCV RNA levels, other factors appear to affect biochemical and virologic markers of HCV infection in some dually infected persons.
Differential antiviral effect of PEG-interferon-α-2b on HIV and HCV in the treatment of HIV/HCV co-infected patients
TLDR
Fitting of HIV kinetics with known half-lives of free virus and infected cells indicates that the major effect of IFN on HIV is to block de novo infection rather than to block virion production.
IMMUNE RECOVERY IS ASSOCIATED WITH PERSISTENT RISE IN HEPATITIS C VIRUS RNA, INFREQUENT LIVER TEST FLARES, AND IS NOT IMPAIRED BY HEPATITIS C VIRUS IN CO-INFECTED SUBJECTS
TLDR
In HCV-co-infected patients undergoing HAART, immune recovery is associated with a persistent increase in HCV RNA, especially with baseline CD4 cell counts < 350 cells/mm3.
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