Antiretroviral regimens in pregnancy and breast-feeding in Botswana.

@article{Shapiro2010AntiretroviralRI,
  title={Antiretroviral regimens in pregnancy and breast-feeding in Botswana.},
  author={R. Shapiro and M. Hughes and A. Ogwu and D. Kitch and S. Lockman and C. Moffat and J. Makhema and S. Moyo and I. Thior and K. Mcintosh and E. van Widenfelt and J. Leidner and K. Powis and A. Asmelash and E. Tumbare and S. Zwerski and U. Sharma and E. Handelsman and K. Mburu and O. Jayeoba and E. Moko and S. Souda and E. Lubega and M. Akhtar and C. Wester and R. Tuomola and W. Snowden and M. Martinez‐Tristani and L. Mazhani and M. Essex},
  journal={The New England journal of medicine},
  year={2010},
  volume={362 24},
  pages={
          2282-94
        }
}
BACKGROUND The most effective highly active antiretroviral therapy (HAART) to prevent mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) in pregnancy and its efficacy during breast-feeding are unknown. METHODS We randomly assigned 560 HIV-1-infected pregnant women (CD4+ count, > or = 200 cells per cubic millimeter) to receive coformulated abacavir, zidovudine, and lamivudine (the nucleoside reverse-transcriptase inhibitor [NRTI] group) or lopinavir-ritonavir plus… Expand
Initiation of antiretroviral treatment in women after delivery can induce multiclass drug resistance in breastfeeding HIV-infected infants.
Antiretroviral use during pregnancy and risk of preterm delivery: more questions than answers.
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