Antiretroviral pre-exposure prophylaxis (PrEP) for preventing HIV in high-risk individuals.

@article{Okwundu2012AntiretroviralPP,
  title={Antiretroviral pre-exposure prophylaxis (PrEP) for preventing HIV in high-risk individuals.},
  author={Charles I. Okwundu and Olalekan Uthman and Christy AN Okoromah},
  journal={The Cochrane database of systematic reviews},
  year={2012},
  volume={7},
  pages={
          CD007189
        }
}
BACKGROUND More than 30 years into the global HIV/AIDS epidemic, infection rates remain alarmingly high, with over 2.7 million people becoming infected every year. There is a need for HIV prevention strategies that are more effective. Oral antiretroviral pre-exposure prophylaxis (PrEP) in high-risk individuals may be a reliable tool in preventing the transmission of HIV. OBJECTIVES To evaluate the effects of oral antiretroviral chemoprophylaxis in preventing HIV infection in HIV-uninfected… Expand
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TLDR
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TLDR
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TLDR
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Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples.
TLDR
ART is a potent intervention for prevention of HIV in discordant couples in which the index partner has ≤550 CD4 cells/µL, and a new multicentre randomised controlled trial confirms the suspected benefit seen in earlier observational studies. Expand
Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples.
TLDR
ART is a potent intervention for prevention of HIV in discordant couples in which the index partner has ≤550 CD4 cells/µL, and this review confirms the suspected benefit seen in earlier observational studies and reported in more recent ones. Expand
Preexposure Prophylaxis for the Prevention of HIV Infection: Evidence Report and Systematic Review for the US Preventive Services Task Force.
TLDR
To synthesize the evidence on the benefits and harms of PrEP, instruments for predicting incident HIV infection, and PrEP adherence to inform the US Preventive Services Task Force, 14 RCTs and 7 studies of diagnostic accuracy were included. Expand
What is the place of pre-exposure prophylaxis in HIV prevention?
TLDR
In conclusion, pre-exposure prophylaxis could be a useful additional tool for the prevention of HIV in specific high-risk groups but should be implemented in a way that deals with issues such as ensuring high adherence and ensuring that it complements, but not detracts from, other more fundamental elements of HIV prevention programs. Expand
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