Antiretroviral pharmacology in pregnant women and their newborns.

  title={Antiretroviral pharmacology in pregnant women and their newborns.},
  author={Mark M Mirochnick},
  journal={Annals of the New York Academy of Sciences},
The physiologic changes of pregnancy have an impact on antiretroviral pharmacokinetic parameters, but the effect is generally not of sufficient magnitude to warrant alterations in dosing. Although administration of oral zidovudine during labor may not provide equivalent serum drug exposure as with continuous intravenous infusion, the clinical relevance of the difference is unknown. Nevirapine is well absorbed during labor, and sufficient drug for prophylaxis against perinatal transmission… CONTINUE READING