Antiretroviral pharmacology in mucosal tissues.

@article{Thompson2013AntiretroviralPI,
  title={Antiretroviral pharmacology in mucosal tissues.},
  author={Corbin G Thompson and Myron S. Cohen and Angela Dm Kashuba},
  journal={Journal of acquired immune deficiency syndromes},
  year={2013},
  volume={63 Suppl 2},
  pages={S240-7}
}
Strategies to prevent HIV infection using preexposure prophylaxis are required to curtail the HIV pandemic. The mucosal tissues of the genital and rectal tracts play a critical role in HIV acquisition, but antiretroviral (ARV) disposition and correlates of efficacy within these tissues are not well understood. Preclinical and clinical strategies to describe ARV pharmacokinetic-pharmacodynamic relationships within mucosal tissues are currently being investigated. In this review, we summarize the… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 10 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 99 references

2012

  • UNAIDS. AIDS Epidemic Updat
  • Available at: http://www. unaids.org/en/media…
  • 2013
1 Excerpt

Gene and protein expression of drug transporters in vaginal, cervical, and rectal tissues: implications for drug disposition in HIV prevention

  • M Nicol, Y Fedoriw, M Mathews
  • Paper presented at: XX Conference on Retroviruses…
  • 2013
1 Excerpt

Long-acting parenteral formulation of GSK1265744 protects macaques against repeated intrarectal challenges with SHIV

  • C Andrews, A Gettie, K Russell-Lodrigue
  • Paper presented at: XX Conference on Retroviruses…
  • 2013
1 Excerpt

Pre-exposure prophylaxis for HIV in women: daily oral tenofovir, oral tenofovir/emtricitabine, or vaginal tenofovir gel in the VOICE study (MTN 003)

  • J Marrazzo, G Ramjje, G Nair
  • Paper presented at: XX Conference on Retroviruses…
  • 2013
1 Excerpt

Prediction of antiretroviral drug penetration into the female genital tract using a novel QSAR model

  • C Thompson, A Sedykh, M Nicol
  • Paper presented at: XIV International Workshop on…
  • 2013
1 Excerpt

Single and multiple dose dolutegravir pharmacokinetics in the genital tract and colorectum of HIV-negative men and women

  • B Greener, J Adams, K. Patterson
  • Paper presented at: XX Conference on Retroviruses…
  • 2013

Similar Papers

Loading similar papers…