Antiretroviral pharmacology in mucosal tissues.

  title={Antiretroviral pharmacology in mucosal tissues.},
  author={Corbin G Thompson and Myron S. Cohen and Angela Dm Kashuba},
  journal={Journal of acquired immune deficiency syndromes},
  volume={63 Suppl 2},
Strategies to prevent HIV infection using preexposure prophylaxis are required to curtail the HIV pandemic. The mucosal tissues of the genital and rectal tracts play a critical role in HIV acquisition, but antiretroviral (ARV) disposition and correlates of efficacy within these tissues are not well understood. Preclinical and clinical strategies to describe ARV pharmacokinetic-pharmacodynamic relationships within mucosal tissues are currently being investigated. In this review, we summarize the… CONTINUE READING
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