Antiretroviral monocyte efficacy score linked to cognitive impairment in HIV.

  title={Antiretroviral monocyte efficacy score linked to cognitive impairment in HIV.},
  author={Cecilia M. Shikuma and Beau Nakamoto and Bruce Shiramizu and Chin-Yuan Liang and Victor DeGruttola and Kara Bennett and Robert H. Paul and Kalpana J. Kallianpur and Dominic C. Chow and Christina Gavegnano and Selwyn J. Hurwitz and Raymond F Schinazi and Victor G. Valcour},
  journal={Antiviral therapy},
  volume={17 7},
BACKGROUND Monocytes transmigrating to the brain play a central role in HIV neuropathology. We hypothesized that the continued existence of neurocognitive impairment (NCI) despite potent antiretroviral (ARV) therapy is mediated by the inability of such therapy to control this monocyte/macrophage reservoir. METHODS Cross-sectional and longitudinal analyses were conducted within a prospectively enrolled cohort. We devised a monocyte efficacy (ME) score based on the anticipated effectiveness of… CONTINUE READING