Antiretroviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase increase template-switching frequency.

@article{Nikolenko2004AntiretroviralDR,
  title={Antiretroviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase increase template-switching frequency.},
  author={Galina N. Nikolenko and Evguenia S Svarovskaia and Krista A Delviks and Vinay K Pathak},
  journal={Journal of virology},
  year={2004},
  volume={78 16},
  pages={
          8761-70
        }
}
Template-switching events during reverse transcription are necessary for completion of retroviral replication and recombination. Structural determinants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) that influence its template-switching frequency are not known. To identify determinants of HIV-1 RT that affect the frequency of template switching, we developed an in vivo assay in which RT template-switching events during viral replication resulted in functional… CONTINUE READING

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