Antiretroviral compounds: mechanisms underlying failure of HAART to eradicate HIV-1.

@article{ShehuXhilaga2005AntiretroviralCM,
  title={Antiretroviral compounds: mechanisms underlying failure of HAART to eradicate HIV-1.},
  author={Miranda Shehu-Xhilaga and Gilda Tachedjian and Suzanne M. Crowe and Katherine Kedzierska},
  journal={Current medicinal chemistry},
  year={2005},
  volume={12 15},
  pages={
          1705-19
        }
}
During the past decade, combined highly active antiretroviral therapy (HAART) consisting of the nucleoside, non-nucleoside and protease inhibitors has improved the outlook for HIV-infected individuals. However, despite the clinical improvement associated with HAART, current antiviral drug regimens are not able to eradicate HIV due to the persistence of virus in cellular reservoirs (predominantly long-lived memory CD4+ T cells and cells of the macrophage lineage) and anatomical sanctuary sites… CONTINUE READING

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