Antiretroviral Pre-exposure Prophylaxis Prevents Vaginal Transmission of HIV-1 in Humanized BLT Mice

@article{Denton2008AntiretroviralPP,
  title={Antiretroviral Pre-exposure Prophylaxis Prevents Vaginal Transmission of HIV-1 in Humanized BLT Mice},
  author={Paul W Denton and Jacob D Estes and Zhifeng Sun and Florence A. Othieno and Bangdong L. Wei and Anja Kathrin Wege and Daniel A. Powell and Deborah A. Payne and Ashley T Haase and J. V{\'i}ctor Garc{\'i}a},
  journal={PLoS Medicine},
  year={2008},
  volume={5},
  pages={1293 - 1294}
}
BACKGROUND Worldwide, vaginal transmission now accounts for more than half of newly acquired HIV-1 infections. Despite the urgency to develop and implement novel approaches capable of preventing HIV transmission, this process has been hindered by the lack of adequate small animal models for preclinical efficacy and safety testing. Given the importance of this route of transmission, we investigated the susceptibility of humanized mice to intravaginal HIV-1 infection. METHODS AND FINDINGS We… CONTINUE READING
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