Antiquorum sensing, antibiofilm formation and cytotoxicity activity of commonly used medicinal plants by inhabitants of Borabu sub-county, Nyamira County, Kenya

@article{Omwenga2017AntiquorumSA,
  title={Antiquorum sensing, antibiofilm formation and cytotoxicity activity of commonly used medicinal plants by inhabitants of Borabu sub-county, Nyamira County, Kenya},
  author={Eric Omori Omwenga and Andreas Hensel and Susana Pereira and Alfred Anakalo Shitandi and Francisco M. Goycoolea},
  journal={PLoS ONE},
  year={2017},
  volume={12}
}
Productions of various bacterial traits like production of virulence factors (e.g. toxins, enzymes), biofilm formation, luminescence among others, have been known to be controlled by quorum sensing (QS), a process that is dependent on chemical signals or autoinducers (AIs). Bacteria known to rely on such AIs are known to be virulent and tend to be resistant against various antimicrobial agents. Therefore, strategies aimed at the inhibition of QS pathways, are regarded as potential novel… Expand
African Plant-Based Natural Products with Antivirulence Activities to the Rescue of Antibiotics
TLDR
An overview on two main aspects: succinct presentation of bacterial virulence and biofilm formation as well as their entanglement through QS mechanisms and detailed reports on African plant extracts and isolated compounds with antivirulence properties against particular pathogenic bacteria are provided. Expand
Seed Extract of Psoralea corylifolia and Its Constituent Bakuchiol Impairs AHL-Based Quorum Sensing and Biofilm Formation in Food- and Human-Related Pathogens
TLDR
The study highlights the anti-infective potential of the PCMF and bakuchiol instead of bactericidal or bacteriostatic action, as the extract targets QS-controlled virulence and the biofilm. Expand
Chitosan nanoencapsulation of flavonoids enhances their quorum sensing and biofilm formation inhibitory activities against an E.coli Top 10 biosensor.
TLDR
The free phytochemicals seemed to be cytotoxic to MDCK-C7 cells at higher doses, however, upon nanoencapsulation, a cytoprotective effect was evidenced and proof-of-principle of the advantages of encapsulation of two bioactive flavonoids was gained. Expand
Assessment of the Quorum Sensing Inhibition Activity of a Non-Toxic Chitosan in an N-Acyl Homoserine Lactone (AHL)-Based Escherichia coli Biosensor
TLDR
Aggregation explains the QS inhibition activity as the consequence of retardation of the diffusion of N-acylated homoserine lactones (AHLs) as well as the antibacterial effect of chitosans against an Escherichia coli quorum sensing biosensor reporter strain. Expand
Inhibitory effect of Newtonia extracts and myricetin-3-o-rhamnoside (myricitrin) on bacterial biofilm formation
Background Diarrhoea is a major health issue in both humans and animals and may be caused by bacterial, viral and fungal infections. Previous studies highlighted excellent activity of NewtoniaExpand
Antimicrobial, cytotoxicity and preliminary phytochemical determination of commonly used medicinal plants to treat oral cavity, urinary tract and gut infections by inhabitants of Borabu sub-county, Nyamira County, Kenya
TLDR
Most of the extracts had no or weak activity against test isolates, but C. didymobotrya leaves extracts showed strong activity against P. gingivalis conditions, which can offer alternative medicare to P. pylori conditions. Expand
1 Assessment of the quorum sensing inhibition activity 2 of a non-toxic chitosan in a AHL-based E . coli 3 biosensor 4
1 Institute of Plant Biology and Biotechnology, University of Münster, Schlossplatz 8, 48143 Münster, Germany; 6 qxf200459420@163.com 7 2School of Food Science and Nutrition, University of Leeds, LS2Expand
ANTIBIOFILM FORMATION ACTIVITY, RESISTANT GENES PROFILING AND DETECTION OF VIRULENCE FACTORS OF TOXIGENIC Vibrio cholerae ISOLATES FROM KISUMU COUNTY, KENYA
TLDR
An understanding of this intricate signaling pathway is essential for the development of methods to treat and prevent this devastating disease. Expand
Modulation of Campylobacter jejuni Motility, Adhesion to Polystyrene Surfaces, and Invasion of INT407 Cells by Quorum-Sensing Inhibition
TLDR
It is shown that natural extracts can reduce motility, adhesion to polystyrene surfaces, and invasion of INT407 cells by C. jejuni through modulation of the LuxS (QS) system. Expand
Chitosan and their derivatives: Antibiofilm drugs against pathogenic bacteria.
TLDR
The present review describes the antibiofilm properties of chitosan and its derivatives against the pathogenic bacteria and summarizes the mechanisms of biofilm inhibition exhibited by these molecules. Expand
...
1
2
...

References

SHOWING 1-10 OF 56 REFERENCES
Quorum sensing inhibitors: an overview.
  • V. Kalia
  • Biology, Medicine
  • Biotechnology advances
  • 2013
TLDR
This review focuses primarily on natural and synthetic quorum sensing inhibitors (QSIs) with the potential for treating bacterial infections and it has been opined that the most versatile prokaryotes to produce QSI are likely to be those, which are generally regarded as safe. Expand
Petunidin as a competitive inhibitor of acylated homoserine lactones in Klebsiella pneumoniae
Most of the bacterial species communicate with each other through a mechanism called Quorum Sensing (QS) to regulate their phenotypic characteristics. Therefore interrupting the bacterialExpand
Autoinducer-2-like activity on vegetable produce and its potential involvement in bacterial biofilm formation on tomatoes.
TLDR
It is suggested that AI-2-like activity, which is present on the surfaces of tomatoes, has the potential to enhance the production of bacterial biofilms. Expand
Baicalein attenuates the quorum sensing-controlled virulence factors of Pseudomonas aeruginosa and relieves the inflammatory response in P. aeruginosa-infected macrophages by downregulating the MAPK and NFκB signal-transduction pathways
TLDR
It is demonstrated that baicalein represents a potential treatment for P. aeruginosa infection because it clearly exhibits both antibacterial and anti-inflammatory activities. Expand
Antimicrobial and cytotoxicity properties of the organic solvent fractions of Clerodendrum myricoides (Hochst.) R. Br. ex Vatke: Kenyan traditional medicinal plant
TLDR
Methanolic fraction had remarkable activity against MRSA, S. aureus, E. sonnei, C. albicans, and MTB, which are of public health concerns due to drug resistance and as sources of community and nosocomial infections. Expand
Rosmarinic acid is a homoserine lactone mimic produced by plants that activates a bacterial quorum-sensing regulator
TLDR
The results indicate that rosmarinic acid secretion is a plant defense mechanism to stimulate a premature quorum-sensing response in P. aeruginosa, a ubiquitous pathogen that infects plants and animals. Expand
Plant food extracts and phytochemicals: Their role as Quorum Sensing Inhibitors
TLDR
This review summarizes the published scientific work on the use of plant food extracts and phytochemicals as Quorum Sensing Inhibitors, highlighting the techniques used to identify their biological activity and their mechanisms of action. Expand
Identification of Small Molecules That Antagonize Diguanylate Cyclase Enzymes To Inhibit Biofilm Formation
TLDR
Seven small molecules that antagonize these enzymes and inhibit biofilm formation by Vibrio cholerae are reported, representing the first compounds described that are able to inhibit DGC activity to prevent biofilm Formation. Expand
Quadruple Quorum-Sensing Inputs Control Vibrio cholerae Virulence and Maintain System Robustness
TLDR
This work shows that two other histidine kinases, CqsR and VpsS, act upstream in the central QS circuit of V. cholerae to activate LuxO, which is essential for virulence of this pathogen. Expand
Going beyond the Control of Quorum-Sensing to Combat Biofilm Infections
TLDR
The broad spectrum of mechanisms, the diversity of bioactive compounds, their activity against several targets, and the conservation of some targets among bacterial pathogens are promising aspects for several clinical applications of this type of biofilm-controlling compound in the future. Expand
...
1
2
3
4
5
...