Antipyrine test predicts pharmacodynamics in docetaxel and cisplatin combination chemotherapy.

@article{Nishio2005AntipyrineTP,
  title={Antipyrine test predicts pharmacodynamics in docetaxel and cisplatin combination chemotherapy.},
  author={Makoto Nishio and Masanori Matsuda and Fumiyoshi Ohyanagi and Yukitohi Sato and Sakae Okumura and Daisuke Tabata and Akinobu Morikawa and Ken Nakagawa and Takeshi Horai},
  journal={Lung cancer},
  year={2005},
  volume={49 2},
  pages={245-51}
}
To clarify the role of cytochrome P450 in docetaxel and cisplatin combination chemotherapy, cytochrome P450 activity was measured by simple antipyrine test, and its correlation with the drugs' pharmacodynamics was assessed. Twenty-five patients with advanced non-small cell lung cancer received an antipyrine test and were treated with docetaxel and cisplatin. Plasma antipyrine concentration (C) was measured 4 and 24h after oral administration of 500 mg antipyrine. Antipyrine disappearance rate… CONTINUE READING