Antipyretics: mechanisms of action and clinical use in fever suppression.

@article{Aronoff2001AntipyreticsMO,
  title={Antipyretics: mechanisms of action and clinical use in fever suppression.},
  author={David M Aronoff and Eric G. Neilson},
  journal={The American journal of medicine},
  year={2001},
  volume={111 4},
  pages={304-15}
}
Fever is a complex physiologic response triggered by infectious or aseptic stimuli. Elevations in body temperature occur when concentrations of prostaglandin E(2) (PGE(2)) increase within certain areas of the brain. These elevations alter the firing rate of neurons that control thermoregulation in the hypothalamus. Although fever benefits the nonspecific immune response to invading microorganisms, it is also viewed as a source of discomfort and is commonly suppressed with antipyretic medication… CONTINUE READING

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