Antipyretic effects of dipyrone versus ibuprofen versus acetaminophen in children: results of a multinational, randomized, modified double-blind study.

@article{Wong2001AntipyreticEO,
  title={Antipyretic effects of dipyrone versus ibuprofen versus acetaminophen in children: results of a multinational, randomized, modified double-blind study.},
  author={Anna Wong and Alexander Sibbald and Fernanda Ferrero and M Plager and Mar{\'i}a Elena Santolaya and Ana Maria de Ulh{\^o}a Escobar and Stalin Campos and Salvador Barragan and M De Le{\'o}n Gonz{\'a}lez and Gustavo Luiz Ferreira Kesselring},
  journal={Clinical pediatrics},
  year={2001},
  volume={40 6},
  pages={313-24}
}
This study compared the antipyretic effectiveness of acetaminophen, ibuprofen, and dipyrone in young children with fever. The results were based on a modified double-blind, randomized, multinational trial that evaluated 628 febrile children, aged 6 months to 6 years. All three drugs lowered temperature in the 555 patients completing the study. Temperature normalization rates in the ibuprofen and dipyrone groups (78% and 82%, respectively) were significantly higher than the acetaminophen group… CONTINUE READING

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