Antipyretic drugs in patients with fever and infection: literature review.

  title={Antipyretic drugs in patients with fever and infection: literature review.},
  author={Jennifer L. Ludwig and Hazel McWhinnie},
  journal={British journal of nursing},
  volume={28 10},
BACKGROUND antipyretic drugs are routinely administered to febrile patients with infection in secondary care. However, the use of antipyretics to suppress fever during infection remains a controversial topic within the literature. It is argued that fever suppression may interfere with the body's natural defence mechanisms, and may worsen patient outcomes. METHOD a literature review was undertaken to determine whether the administration of antipyretic drugs to adult patients with infection and… 
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Background: Fever is suppressed with drugs due to discomfort and risk of organ damage. However, there is some compelling evidence for the benefits of fever. The elderly are a special population in
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It is plausible to hypothesize that the antipyretic efficacy of ibuprofen may be hindering the benefits of a fever response when taken during the early stages of COVID-19 illness.
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In adult age group patients admitted to the emergency department with high fever, the IV forms of 1000 mg paracetamol and 400 mg ibuprofen effectively and equally reduce complaints, such as fever and accompanying pain.
Effect of a fever in viral infections — the ‘Goldilocks’ phenomenon?
The risks and benefits of a fever on the host response are discussed, focusing on the effects of a Fever on viral replication and host response, and the detrimental effect on theHost.
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The applying of educational protocol among mothers was effective in enhancing their knowledge, and practices regarding types of fever and their management and recommended further educational protocols in the pediatric clinics or via mass media for mothers about fever should be implemented.
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Literature review: should antipyretic therapies routinely be administered to patients with [corrected] fever?
The evidence on which to base recommendations for practice is weak but does not support the current practice of administering antipyretic therapies routinely to patients with fever, and physical cooling methods alone should never be used.
Fever effects and treatment in critical care: literature review.
Significant implications for antipyretic treatment of critically ill adults are provided and areas for future research are suggested, including fever suppression and return to normothermia improved outcomes of septic shock patients.
Fever and Antipyretic Use in Children
The primary goal of treating the febrile child should be to improve the child's overall comfort rather than focus on the normalization of body temperature, and Pediatricians should also promote patient safety by advocating for simplified formulations, dosing instructions, and dosing devices.
Clinical and Demographic Factors Associated with Antipyretic Use in Gram-Negative Severe Sepsis and Septic Shock
Most febrile episodes in patients with gram-negative severe sepsis or septic shock were not treated with antipyretic medications, and further studies are needed to demonstrate the effect of antipYretics on clinically relevant outcomes in severe sePSis and septicshock.
Early antipyretic exposure does not increase mortality in patients with gram-negative severe sepsis: a retrospective cohort study
Early antipyretic therapy is not associated with increased mortality in febrile patients with gram-negative bacteremia hospitalized with severe sepsis or septic shock, and this study was a single-center retrospective cohort study.
Pharmacological versus non-pharmacological antipyretic treatments in febrile critically ill adult patients: a systematic review and meta-analysis.
  • N. Hammond, M. Boyle
  • Medicine
    Australian critical care : official journal of the Confederation of Australian Critical Care Nurses
  • 2011
The authors' main findings include, newer versus conventional external cooling therapies where newer external cooling methods were better at reducing the fever burden than conventional methods (surface cooling) and reduction on core body temperature favoured continuous antipyretic infusions rather than bolus doses.
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A pilot, open-label clinical trial that randomized febrile patients to an aggressive or permissive fever control strategy demonstrated the safety and feasibility of administering antipyretic therapy in critically ill adults.