Antipyretic drugs in patients with fever and infection: literature review.

@article{Ludwig2019AntipyreticDI,
  title={Antipyretic drugs in patients with fever and infection: literature review.},
  author={Jennifer L. Ludwig and Hazel McWhinnie},
  journal={British journal of nursing},
  year={2019},
  volume={28 10},
  pages={
          610-618
        }
}
BACKGROUND antipyretic drugs are routinely administered to febrile patients with infection in secondary care. However, the use of antipyretics to suppress fever during infection remains a controversial topic within the literature. It is argued that fever suppression may interfere with the body's natural defence mechanisms, and may worsen patient outcomes. METHOD a literature review was undertaken to determine whether the administration of antipyretic drugs to adult patients with infection and… 
Long-term health effects of antipyretic drug use in the ageing population: protocol for a systematic review
TLDR
This study aims to provide the synthesized best evidence regarding long-term health effects of antipyretic treatment in the elderly during infections, investigating the onset/worsening of common chronic diseases, for e.g., thyroid disorders, connective tissue diseases and chronic obstructive pulmonary disease/asthma.
Long-term health effects of antipyretic drug use in the ageing population: protocol for a systematic review [version 1; peer review: 1 approved]
Background: Fever is suppressed with drugs due to discomfort and risk of organ damage. However, there is some compelling evidence for the benefits of fever. The elderly are a special population in
The use of ibuprofen to treat fever in COVID-19: A possible indirect association with worse outcome?
TLDR
It is plausible to hypothesize that the antipyretic efficacy of ibuprofen may be hindering the benefits of a fever response when taken during the early stages of COVID-19 illness.
Comparison of intravenous ibuprofen and paracetamol in the treatment of fever: A randomized double-blind study.
TLDR
In adult age group patients admitted to the emergency department with high fever, the IV forms of 1000 mg paracetamol and 400 mg ibuprofen effectively and equally reduce complaints, such as fever and accompanying pain.
Effect of a fever in viral infections — the ‘Goldilocks’ phenomenon?
TLDR
The risks and benefits of a fever on the host response are discussed, focusing on the effects of a Fever on viral replication and host response, and the detrimental effect on theHost.
Helicobacter canis bacteraemia in a rheumatoid arthritis patient treated with tofacitinib: case report and literature review
TLDR
Clinicians should recognise H. canis infection risk in patients with recent pet exposure and predisposing factors such as immunodeficiency disorders or diseases that demand immunosuppressive drug therapy.
Educational Protocol for Improving Mothers Practices on the Types of Fever in Zagazig City
TLDR
The applying of educational protocol among mothers was effective in enhancing their knowledge, and practices regarding types of fever and their management and recommended further educational protocols in the pediatric clinics or via mass media for mothers about fever should be implemented.
Identification of compounds with antipyretic effects and anti-endotoxin activity in different species of Lonicera japonica using spectrum-effect correlation
TLDR
The aim of the present study was to investigate the underlying correlations between common chemical compounds with antipyretic effects and the anti-endotoxin activity of Lonicera japonica.
Enhancing innate immunity against virus in times of COVID-19: Trying to untangle facts from fictions
TLDR
Several interventions have some degree of evidence for enhancing the innate immune response and thus conveying possible benefit, but specific trials in COVID-19 should be conducted to support solid recommendations.
Scrutinizing pharmacological efficiency for Acacia auriculiformis by experimental and computational approach
The study sought to investigate the biological efficacy of methanol leave extract of Acacia auriculiformis (MEAA) via in vitro, in vivo, in silico approaches. The in vitro cytotoxicity was evaluated

References

SHOWING 1-10 OF 31 REFERENCES
Literature review: should antipyretic therapies routinely be administered to patients with [corrected] fever?
TLDR
The evidence on which to base recommendations for practice is weak but does not support the current practice of administering antipyretic therapies routinely to patients with fever, and physical cooling methods alone should never be used.
Fever effects and treatment in critical care: literature review.
TLDR
Significant implications for antipyretic treatment of critically ill adults are provided and areas for future research are suggested, including fever suppression and return to normothermia improved outcomes of septic shock patients.
Fever and Antipyretic Use in Children
TLDR
The primary goal of treating the febrile child should be to improve the child's overall comfort rather than focus on the normalization of body temperature, and Pediatricians should also promote patient safety by advocating for simplified formulations, dosing instructions, and dosing devices.
Clinical and Demographic Factors Associated with Antipyretic Use in Gram-Negative Severe Sepsis and Septic Shock
TLDR
Most febrile episodes in patients with gram-negative severe sepsis or septic shock were not treated with antipyretic medications, and further studies are needed to demonstrate the effect of antipYretics on clinically relevant outcomes in severe sePSis and septicshock.
Early antipyretic exposure does not increase mortality in patients with gram-negative severe sepsis: a retrospective cohort study
TLDR
Early antipyretic therapy is not associated with increased mortality in febrile patients with gram-negative bacteremia hospitalized with severe sepsis or septic shock, and this study was a single-center retrospective cohort study.
Pharmacological versus non-pharmacological antipyretic treatments in febrile critically ill adult patients: a systematic review and meta-analysis.
  • N. Hammond, M. Boyle
  • Medicine
    Australian critical care : official journal of the Confederation of Australian Critical Care Nurses
  • 2011
TLDR
The authors' main findings include, newer versus conventional external cooling therapies where newer external cooling methods were better at reducing the fever burden than conventional methods (surface cooling) and reduction on core body temperature favoured continuous antipyretic infusions rather than bolus doses.
Clinical review: Fever in septic ICU patients - friend or foe?
TLDR
The advantages and drawbacks of fever in septic patients are delineated and the treatment of fever by pharmacological and/or physical means is discussed with regards to their drawbacks, which argues for their careful use in sepsis patients in the absence of clinical relevance.
Antipyretic Therapy in Critically Ill Septic Patients: A Systematic Review and Meta-Analysis
TLDR
Antipyretic treatment does not significantly improve 28-day/hospital mortality in adult patients with sepsis, and results included mortality, frequency of shock reversal, acquisition of nosocomial infections, and changes in body temperature, heart rate, and minute ventilation.
Antipyretic agents for preventing recurrences of febrile seizures: randomized controlled trial.
TLDR
Antipyretic agents are ineffective for the prevention of recurrences of febrile seizures and for the lowering of body temperature in patients with a feBrile episode that leads to a recurrent febRIle seizure.
Assessment of the safety and feasibility of administering antipyretic therapy in critically ill adults: a pilot randomized clinical trial.
TLDR
A pilot, open-label clinical trial that randomized febrile patients to an aggressive or permissive fever control strategy demonstrated the safety and feasibility of administering antipyretic therapy in critically ill adults.
...
1
2
3
4
...