Antipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model

@inproceedings{Naviaux2013AntipurinergicTC,
  title={Antipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model},
  author={Robert K. Naviaux and Zarazuela Zolkipli and Lin Wang and Tomohiro Nakayama and Jane C. Naviaux and Thuy P. Le and Michael A. Schuchbauer and Mihael Rogac and Qingbo Tang and Laura L. Dugan and Susan B. Powell},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND Autism spectrum disorders (ASDs) are caused by both genetic and environmental factors. Mitochondria act to connect genes and environment by regulating gene-encoded metabolic networks according to changes in the chemistry of the cell and its environment. Mitochondrial ATP and other metabolites are mitokines-signaling molecules made in mitochondria-that undergo regulated release from cells to communicate cellular health and danger to neighboring cells via purinergic signaling. The role… CONTINUE READING
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