Antipsychotics increase vesicular glutamate transporter 2 (VGLUT2) expression in thalamolimbic pathways

@article{Moutsimilli2008AntipsychoticsIV,
  title={Antipsychotics increase vesicular glutamate transporter 2 (VGLUT2) expression in thalamolimbic pathways},
  author={Larissa Moutsimilli and S{\'e}verine Farley and M. Khoury and Christophe Chamot and Jean-Baptiste Sibarita and Victor Racine and Salah El Mestikawy and Flavie Mathieu and Sylvie Dumas and Bruno Giros and Eleni T. Tzavara},
  journal={Neuropharmacology},
  year={2008},
  volume={54},
  pages={497-508}
}
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The trafficking of VGLUT2 is explored using a pHluorin-based reporter and sorting signals in the C-terminal dileucine-like motif are characterized, which plays a crucial role in V GLUT2 trafficking.
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TLDR
This review summarizes the current knowledge on effects of FGAs and SGAs on glutamate transport and receptor expression derived from pharmacological studies and indicates that serotonergic effects of SGAs represent important targets for further clinical research.
Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: Effects of fluoxetine and MK-801
Vesicular glutamate transporter VGLUT1 has a role in hippocampal long-term potentiation and spatial reversal learning.
TLDR
It is reported that deletion of VGLUT1 resulted in impaired hippocampal long-term potentiation (LTP) in the CA1 region in vitro, and a functional role of V GLUT1 in forms of hippocampal synaptic plasticity that are required to adapt and modify acquired spatial maps to external stimuli and changes is suggested.
Altered Functionality, Morphology, and Vesicular Glutamate Transporter Expression of Cortical Motor Neurons from a Presymptomatic Mouse Model of Amyotrophic Lateral Sclerosis.
TLDR
Functional and structural neuronal alterations associate with abnormal glutamatergic activity in motor cortex of presymptomatic G93A mice provide strong support for the view that upper motor neurons are involved early on in the pathogenesis of ALS.
Neurodevelopmental Role for VGLUT2 in Pyramidal Neuron Plasticity, Dendritic Refinement, and in Spatial Learning
TLDR
The data indicate that VGLUT2 expression is pivotal to the proper development of mature pyramidal neuronal architecture and plasticity, and that such glutamatergic deficiency leads to cognitive malfunction as observed in several neurodevelopmental psychiatric disorders.
From glutamate co-release to vesicular synergy: vesicular glutamate transporters
TLDR
Questions are raised about the morphological and functional organization of neuronal systems endowed with such a dual signalling capacity and the behavioural relevance of this co-phenotype is presently the focus of considerable interest.
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