Antipsychotics as antidepressants

@article{Roberts2016AntipsychoticsAA,
  title={Antipsychotics as antidepressants},
  author={Rona Jeannie Roberts and Kavita Lohano and Rif S El-Mallakh},
  journal={Asia‐Pacific Psychiatry},
  year={2016},
  volume={8},
  pages={179 - 188}
}
Three second‐generation antipsychotic (SGA) agents have received FDA approval for adjunctive treatment, to antidepressant, of major depressive disorder: quetiapine, aripiprazole, and olanzapine. Additionally, quetiapine and lurasidone have been approved for the treatment of bipolar depression. There are data suggesting that quetiapine is effective for major depressive disorder as monotherapy. These agents are effective for depression only at subantipsychotic doses. Receptor profiles predict… 
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