Antipsychotics and the risk of sudden cardiac death.

@article{Ray2001AntipsychoticsAT,
  title={Antipsychotics and the risk of sudden cardiac death.},
  author={Wayne A. Ray and Sarah Meredith and Purushottam B. Thapa and Keith G. Meador and Kathi Hall and Katherine T. Murray},
  journal={Archives of general psychiatry},
  year={2001},
  volume={58 12},
  pages={
          1161-7
        }
}
BACKGROUND Case reports link antipsychotic drugs with sudden cardiac deaths, which is consistent with dose-related electrophysiologic effects. Because this association has not been confirmed in controlled studies, we conducted a retrospective cohort study in Tennessee Medicaid enrollees, which included many antipsychotic users; there were also computer files describing medication use and comorbidity. The study was conducted before the introduction of risperidone and, thus, did not include the… 
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Antipsychotics and the risk of sudden cardiac death.
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Current use of antipsychotics in a general population is associated with an increased risk of sudden cardiac death, even at a low dose and for indications other than schizophrenia.
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Current users of typical and of atypical antipsychotic drugs had a similar, dose-related increased risk of sudden cardiac death.
Risk of serious cardiac events in older adults using antipsychotic agents.
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Physicians should always evaluate patients for comorbid conditions, especially heart disease and metabolic abnormalities, and all currently used medications to assure a risk-to-benefit ratio favoring the application of an antipsychotic medication.
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Treatment with any antipsychotic drug was associated with out–of–hospital cardiac arrest (OHCA), as was use with typical antipsychotics, as was one atypical antippsychotic drug, quetiapine.
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Cardiac safety of antipsychotic drugs continues to be a concern for both typical and atypical antipsychotics. Risk appears greatest in those with pre-existing cardiac disease but many patients may…
Antipsychotic Drugs and the Risk of Ventricular Arrhythmia and/or Sudden Cardiac Death: A Nation‐wide Case‐Crossover Study
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Use of antipsychotic drugs is associated with an increased risk of VA and/or SCD, and the association was significantly higher among those with short‐term use.
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Current agents used for DRP were associated with increased risk of death and adverse outcomes and persisted with long-term use.
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This large, population-based study from Canada assessed the risk for death after dispensation of antipsychotics in older adults with dementia and concluded that improvements in behavioral symptoms with antipsychotic drug treatment do not necessarily lead to improvements in overall quality of life for patients or their caregivers.
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