Antipsychoticlike effects of amoxapine, without catalepsy, using the prepulse inhibition of the acoustic startle reflex test in rats

  title={Antipsychoticlike effects of amoxapine, without catalepsy, using the prepulse inhibition of the acoustic startle reflex test in rats},
  author={Marie-Louise G. Wadenberg and Terrence L. Sills and Paul J. Fletcher and Shitij Kapur},
  journal={Biological Psychiatry},
Actions of Novel Antipsychotic Agents on Apomorphine-Induced PPI Disruption: Influence of Combined Serotonin 5-HT1A Receptor Activation and Dopamine D2 Receptor Blockade
Antipsychotics possessing agonist efficacy at 5-HT1A receptors exhibit diverse profiles against apomorphine-induced PPI deficits, depending on the balance between D2 and 5- HT1A activities, suggesting that they may display distinct activity on some aspects of gating deficits in schizophrenic patients.
Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review
While the PPI model based on the effects of direct DA agonists is the most well-validated for the identification of known antipsychotic drugs, the isolation rearing model also appears to be sensitive to both typical and atypical antipsychotics, and the 5-HT P PI model is less generally sensitive to antippsychotic medications, but can provide insight into the contribution of serotonergic systems to the actions of newer antipsychosis that act upon multiple receptors.
Study on Role of Antidepressant Drug in Antipsychotic like Effect of Clozapine in Rats
The participation of antidepressant drug in antipsychotic like effect of clozapine was demonstrated and dose dependent suppression of condition avoidance response was shown.
The effects of the dopamine D2 agonist sumanirole on prepulse inhibition in rats
Amoxapine as an Atypical Antipsychotic: A Comparative Study Vs Risperidone
Since amoxapine is off-patent, it may be a valuable low-cost alternative to new atypical antipsychotic drugs, particularly in low-income countries where the majority of the patients are still treated with typical antipsychotics.
Mutual independence of 5-HT2 and α1 noradrenergic receptors in mediating deficits in sensorimotor gating
5-HT2 receptors and α1 and β NE receptors may act through independent mechanisms to modulate sensorimotor gating and locomotor activity and modify PPI.
Effect of 5-HT2A receptor antagonism on levels of D2/3 receptor occupancy and adverse behavioral side-effects induced by haloperidol: a SPECT imaging study in the rat
A partial contribution of a 5-HT 2A R antagonism to the efficacy and side-effect profile of antipsychotic agents is suggested.
Interaction of the Dopaminergic and Serotonergic Systems in Rat Brain
The role of 5-HT neurons in the striatal dopaminergic imbalance that is responsible for the rotational behavior seen in the unilateral 6-OHDA rat is highlighted.
Pre-attentive processing and schizophrenia: animal studies
Both paradigm offer the possibility of developing novel therapeutic targets for the cognitive deficits in schizophrenia, however, such an approach will only be successful when a further integration between clinical and pre-clinical research takes place.


DOI disruption of prepulse inhibition of startle in the rat is mediated by 5-HT(2A) and not by 5-HT(2C) receptors.
The view that MDL 100,907 may be a novel atypical antipsychotic is supported and the hypothesis that the 5-HT(2A) receptor is involved in the modulation of sensorimotor gating is supported.
Serotonergic mechanisms in neuroleptic-induced catalepsy in the rat
  • M. Wadenberg
  • Biology, Psychology
    Neuroscience & Biobehavioral Reviews
  • 1996
Selective dopamine D4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition
Results suggest that dopamine receptor antagonists with selectivity for the D4 dopamine receptor subtype may be effective in the treatment of schizophrenia, while being less likely to produce dyskinesias associated with D2 receptor antagonists.
The neuropharmacological actions of amoxapine.
Evidence is offered that the conversion of the tertiary terminal nitrogen to a secondary amine may alter the pharmacologica properties of dibenzoxazepines in a similar way to the for the phenothiazines.