Antipsychotic profiles of TASP0443294, a novel and orally active positive allosteric modulator of metabotropic glutamate 2 receptor.

@article{Hikichi2015AntipsychoticPO,
  title={Antipsychotic profiles of TASP0443294, a novel and orally active positive allosteric modulator of metabotropic glutamate 2 receptor.},
  author={Hirohiko Hikichi and Tetsuaki Hiyoshi and Toshiyuki Marumo and Yasumitsu Tomishima and Ayaka Kaku and Izumi Iida and Hiroki Urabe and Tomoko Tamita and Akito Yasuhara and Jun-ichi Karasawa and Shigeyuki Chaki},
  journal={Journal of pharmacological sciences},
  year={2015},
  volume={127 3},
  pages={352-61}
}
Glutamatergic dysfunction has been implicated in psychiatric disorders such as schizophrenia. The stimulation of metabotropic glutamate (mGlu) 2 receptor has been shown to be effective in a number of animal models of schizophrenia. In this study, we investigated the antipsychotic profiles of (2S)-5-methyl-2-{[4-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]methyl}-2,3-dihydroimidazo[2,1-b][1,3]oxazole-6-carboxamide (TASP0443294), a newly synthesized positive allosteric modulator of the mGlu2… CONTINUE READING