Antipsychotic medication and prefrontal cortex activation: A review of neuroimaging findings

@article{Liemburg2012AntipsychoticMA,
  title={Antipsychotic medication and prefrontal cortex activation: A review of neuroimaging findings},
  author={E. Liemburg and H. Knegtering and H. Klein and R. Kortekaas and A. Aleman},
  journal={European Neuropsychopharmacology},
  year={2012},
  volume={22},
  pages={387-400}
}
  • E. Liemburg, H. Knegtering, +2 authors A. Aleman
  • Published 2012
  • Medicine, Psychology
  • European Neuropsychopharmacology
  • Decreased prefrontal activation (hypofrontality) in schizophrenia is thought to underlie negative symptoms and cognitive impairments, and may contribute to poor social outcome. Hypofrontality does not always improve during treatment with antipsychotics. We hypothesized that antipsychotics, which share antagonism at dopamine receptors, with a relatively low dopamine receptor affinity and high serotonin receptor affinity may have a sparing effect on prefrontal function compared to strong dopamine… CONTINUE READING
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