Antipsychotic-induced hyperprolactinemia inhibits the hypothalamo-pituitary-gonadal axis and reduces bone mineral density in male patients with schizophrenia.

@article{Kishimoto2008AntipsychoticinducedHI,
  title={Antipsychotic-induced hyperprolactinemia inhibits the hypothalamo-pituitary-gonadal axis and reduces bone mineral density in male patients with schizophrenia.},
  author={Taishiro Kishimoto and Koichiro Watanabe and Naoki Shimada and Kazuya Makita and Gohei Yagi and Haruo Kashima},
  journal={The Journal of clinical psychiatry},
  year={2008},
  volume={69 3},
  pages={385-91}
}
OBJECTIVE An inhibitory effect of hyperprolactinemia on the hypothalamo-pituitary-gonadal axis has been suggested as a mechanism of bone loss in schizophrenia, but this has not been confirmed. In this study, which was conducted in Tokyo, Japan, from February to May 2005, we examined the possible causes of reduced bone mineral density (BMD) in male patients with schizophrenia. METHOD The BMD of the radius of 74 male patients (aged 31-78 years) who met the diagnostic criteria for DSM-IV… CONTINUE READING
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