Antipsychotic-evoked dopamine supersensitivity

@article{Servonnet2020AntipsychoticevokedDS,
  title={Antipsychotic-evoked dopamine supersensitivity},
  author={Alice Servonnet and Anne-No{\"e}l Samaha},
  journal={Neuropharmacology},
  year={2020},
  volume={163}
}
  • Alice Servonnet, Anne-Noël Samaha
  • Published 2020
  • Psychology, Medicine
  • Neuropharmacology
  • All antipsychotic medications attenuate the symptoms of psychosis by interacting with dopamine D2 receptors and reducing dopamine-mediated neurotransmission. However, long-term antipsychotic treatment can produce neuroadaptations that are thought to lead to dopamine supersensitivity. In patients with schizophrenia, this dopamine supersensitivity could compromise treatment efficacy, promote relapse to psychosis and trigger movement disorders. Such effects have been seen in patients treated with… CONTINUE READING

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