Antipsychotic drugs inhibit the function of breast cancer resistance protein.

  title={Antipsychotic drugs inhibit the function of breast cancer resistance protein.},
  author={Jun-sheng Wang and Hao-jie Zhu and John Seth Markowitz and Jennifer L. Donovan and Hong-Jie Yuan and C Lindsay Devane},
  journal={Basic & clinical pharmacology & toxicology},
  volume={103 4},
The ABCG2 transporter breast cancer resistance protein (BCRP) has been identified in several physiological sites. It has been suggested to play an important role in disposition of many drugs and environmental toxins. We investigated the effects of several antipsychotic drugs, including risperidone, 9-hydroxy-risperidone (paliperidone), olanzapine, quetiapine, clozapine, haloperidol and chlorpromazine, and a positive control inhibitor Ko143 on functions of BCRP in MCF7 and BCRP over-expressing… CONTINUE READING


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