Antipsychotic drugs affect glucose uptake and the expression of glucose transporters in PC12 cells

@article{Dwyer1999AntipsychoticDA,
  title={Antipsychotic drugs affect glucose uptake and the expression of glucose transporters in PC12 cells},
  author={Donard S Dwyer and Harold B. Pinkofsky and Ye Liu and Ronald J. Bradley},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={1999},
  volume={23},
  pages={69-80}
}
1. Adherence of the PC12 cell line to poly-l-lysine (PLL) on tissue culture dishes stimulated glucose transport into the cells. Fluphenazine, chlorpromazine, clozapine and haloperidol inhibited glucose uptake in this system after a short (30 min) preincubation with drug. The IC50's for this effect were typically in the range of 5-40 microM. 2. Following longer exposures of the drugs (24 hr), there was a significant increase (approximately 3-fold) in the cellular levels of the glucose… CONTINUE READING

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