Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection.

@article{Lieberman2008AntipsychoticDC,
  title={Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection.},
  author={Jeffrey A. Lieberman and Frank P. Bymaster and Herbert Y Meltzer and Ariel Y. Deutch and Gary E. Duncan and C. E. Marx and June R. Aprille and Donard S Dwyer and Xin-Min Li and Sahebarao Prabhu Mahadik and Ronald S Duman and Joseph H. Porter and Josephine S. Modica-Napolitano and Samuel Sathyanesan Newton and John G. Csernansky},
  journal={Pharmacological reviews},
  year={2008},
  volume={60 3},
  pages={358-403}
}
Various lines of evidence indicate the presence of progressive pathophysiological processes occurring within the brains of patients with schizophrenia. By modulating chemical neurotransmission, antipsychotic drugs may influence a variety of functions regulating neuronal resilience and viability and have the potential for neuroprotection. This article reviews the current literature describing preclinical and clinical studies that evaluate the efficacy of antipsychotic drugs, their mechanism of… CONTINUE READING

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