Antipsychotic drug treatment induces differential gene expression in the rat cortex.

@article{Kontkanen2002AntipsychoticDT,
  title={Antipsychotic drug treatment induces differential gene expression in the rat cortex.},
  author={Outi Kontkanen and Petri T{\"o}r{\"o}nen and Merja Lakso and Garry Wong and Eero Castr{\'e}n},
  journal={Journal of neurochemistry},
  year={2002},
  volume={83 5},
  pages={1043-53}
}
Antipsychotic drug treatment is known to modulate gene expression in experimental animals. In this study, candidate target genes for antipsychotic drug action were searched using microarrays after acute clozapine treatment (1, 6 and 24 h) in the rat prefrontal cortex. Microarray data clustering with a self-organizing map algorithm revealed differential expression of genes involved in presynaptic function following acute clozapine treatment. The differential expression of 35 genes most… CONTINUE READING
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