Antipsychotic drug effects on glutamatergic activity

@article{Lidsky1997AntipsychoticDE,
  title={Antipsychotic drug effects on glutamatergic activity},
  author={Theodore I. Lidsky and Elena Yablonsky-Alter and L. Zuck and S. P. Banerjee},
  journal={Brain Research},
  year={1997},
  volume={764},
  pages={46-52}
}
The role of glutamate receptors in antipsychotic drug action
TLDR
It is found that long-term administration of the typical neuroleptic haloperidol and the atypical one clozapine increased the number ofNMDA receptors labelled with [3H]CGP 39653 in different cortical areas, suggesting that an increase in the density of cortical NMDA receptors may be important to a longterm neuroleptics therapy.
Indirect Modulation of Dopamine D2 Receptors as Potential Pharmacotherapy for Schizophrenia: II. Glutamate (Ant)Agonists
TLDR
Preclinical and clinical data suggest the possible use of glutamate receptor agonists or antagonists as novel antipsychotic agents, and a role for glutamate in the pathogenesis or pharmacotherapy of schizophrenia is suggested from anatomic, physiologic, and pharmacologic evidence.
Regulation of Ionotropic Glutamatergic Mechanisms Following Treatment with Chlorpromazine
TLDR
Data presented in this study on the influence of CPZ on the ionotropic glutamatergic mechanisms allow to understand the multifaceted mechanisms action of neuroleptic in protection against deterioration of mental disorders such as schizophrenia.
Neuropsychopharmacological actions of taurine.
TLDR
Taurine administration was found to prevent cocaine-induced addiction by suppressing spontaneous locomotor activity and conditioned place preference, and both taurine and endomorphin-1 were found to suppress the delayed broad negative evoked field potentials in anterior insular cortex (upper layer 5) by partially inhibiting NMDA receptor system.
Inhibition of human alpha1E subunit-mediated ca2+ channels by the antipsychotic agent chlorpromazine.
Chlorpromazine is a neuroleptic antipsychotic agent with a long history of clinical use. Its primary mode of action is thought to be through modulation of monoaminergic inter-neuronal communication;
Indirect modulation of dopamine D2 receptors as potential pharmacotherapy for schizophrenia: III. Retinoids
TLDR
This article focuses on the postulated use of retinoid analogs as novel antipsychotic agents when used either as monotherapy or as adjunct pharmacotherapy to dopamine D2 receptor antagonists.
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It is shown that the conventional neuroleptic haloperidol and the atypical antipsychotic clozapine had potent augmenting influences on the NMDA receptor, suggesting that unique action at glutamate receptors may contribute to antipsychotics efficacy and emphasize the potential importance of glutamatergic dysfunction in the etiology of schizophrenia.
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Findings indicate that the dopaminergic antagonist properties of haloperidol are likely most responsible for its regulation of this subunit, consistent with the relatively weaker influence of this drug on nigrostriatal DA function.
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Effects of Subchronic Clozapine and Haloperidol on Striatal Glutamatergic Synapses
TLDR
The data suggest that some neuroleptic effects may be mediated by glutamatergic systems and that typical and atypical antipsychotics can have varying effects on the density of glutamate in presynaptic terminals and on the expression of specific NMDA receptor splice variant mRNAs.
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