Antipsychotic drug action on SREBPs-related lipogenesis and cholesterogenesis in primary rat hepatocytes

@article{Lauressergues2010AntipsychoticDA,
  title={Antipsychotic drug action on SREBPs-related lipogenesis and cholesterogenesis in primary rat hepatocytes},
  author={Emilie Lauressergues and Bart Staels and Karine Valeille and Zouher Majd and Dean W. Hum and Patrick Duriez and Didier Cussac},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2010},
  volume={381},
  pages={427-439}
}
The use of some of antipsychotic drugs (APDs) in humans has been hampered by the induction of metabolic disorders such as weight gain, dyslipidemia, and diabetes. In primary rat hepatocytes, we investigated the actions of several APDs on lipid and cholesterol metabolism using [14C]acetate incorporation, quantitative reverse transcription-polymerase chain reaction, and western blotting. Clozapine and olanzapine, known to have significant metabolic side effects in man, strongly increased de novo… CONTINUE READING
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SAS system for mixed models

  • RC Littell, G Miliken, WW Stroup, RD Wolfinger
  • SAS Institute Inc.,
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