Antipsychotic Polypharmacy: Is There Evidence for its Use?

@article{Patrick2005AntipsychoticPI,
  title={Antipsychotic Polypharmacy: Is There Evidence for its Use?},
  author={Vijayalakshmy Patrick and Elizabeth Levin and Steven J. Schleifer},
  journal={Journal of Psychiatric Practice},
  year={2005},
  volume={11},
  pages={248-257}
}
Antipsychotic polypharmacy occurs frequently in clinical practice; however, there is a lack of controlled clinical studies testing the efficacy of the combinations used. The purpose of this literature review was to examine studies and other reports that have assessed the incremental benefits and deficits of combination antipsychotic therapy versus monotherapy. A PUBMED search covering a 26-year period from 1976 to 2002 was conducted. The search was limited to clinical trials, case series, and… 

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A synthesis of the available literature on the range and efficacy of clozapine augmentation strategies that may be used when monotherapy fails shows that current systematic efforts to enhance the treatment of patients with adjunctive therapies are worthy of being studied in carefully conducted clinical trials.

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Antipsychotic Polypharmacy: A Survey of Discharge Prescriptions from a Tertiary Care Psychiatric Institution

Although antipsychotic polypharmacy persists today, as it has over the past 30 years, evidence-based data to support this controversial treatment strategy is lacking and clinicians are relying on their clinical experience, and perhaps intuition, to design antipsychotics polyphARMacy treatment protocols.

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