Antipsychotic-Like Actions of the Satiety Peptide, Amylin, in Ventral Striatal Regions Marked by Overlapping Calcitonin Receptor and RAMP-1 Gene Expression

  title={Antipsychotic-Like Actions of the Satiety Peptide, Amylin, in Ventral Striatal Regions Marked by Overlapping Calcitonin Receptor and RAMP-1 Gene Expression},
  author={Sarah K. Baisley and Quentin Z Bremer and V. Bakshi and B. Baldo},
  journal={The Journal of Neuroscience},
  pages={4318 - 4325}
Amylin is a calcitonin-related peptide co-secreted with insulin, which produces satiety through brainstem-localized receptors; however, its effects in forebrain are poorly understood. The nucleus accumbens shell (AcbSh) exhibits among the densest concentrations of high-affinity amylin binding; nevertheless, these receptors have not been explored beyond one study showing dopamine antagonist-like effects of intra-Acb amylin on feeding and associated behavior (Baldo and Kelley, 2001). Here, we… Expand
Amylin Receptor Signaling in the Nucleus Accumbens Negatively Modulates μ-opioid-Driven Feeding
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The wider distribution of amylin in birds as compared to rodents suggests a more general role in social or other behaviours in avian species than in mammals, and parental care in birds may be a more complex behavioural trait involving a wider set of brain regions. Expand
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Amylin Receptor Signaling in the Ventral Tegmental Area is Physiologically Relevant for the Control of Food Intake
It is shown that mRNA for all components of the amylin receptor complex is expressed in the ventral tegmental area (VTA), a mesolimbic structure mediating food intake and reward, suggesting that amylIn receptor signaling in the VTA is physiologically relevant for food intake control and potentially clinically relevant for the treatment of obesity. Expand
Differential Calcitonin Gene‐Related Peptide (CGRP) and Amylin Binding Sites in Nucleus Accumbens and Lung: Potential Models for Studying CGRP/Amylin Receptor Subtypes
The data from these studies demonstrate both species and tissue differences in the existence of distinct CGRP and amylin binding sites and present a potential opportunity to study further C GRP andAmylin receptor subtypes. Expand
Amylin infusion into rat nucleus accumbens potently depresses motor activity and ingestive behavior.
  • B. Baldo, A. Kelley
  • Chemistry, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2001
The Acb may be a target for behavioral regulation by satiety-related peptides like amylin, which exerts anorexic effects on central administration through infusions into Acb subregions and reduces motor activity in nondeprived rats tested in the absence of food or water. Expand
Dopamine D(2) receptors mediate amylin's acute satiety effect.
The results suggest that the dopaminergic system mediates part of amylin's inhibitory effect on feeding in rats when administered intraperitoneally, and seems to involve DA D(2) receptors but not D(1) receptors. Expand
Behavioral effects of amylin injected intracerebroventricularly in the rat
The results suggest that amylin may exert motor effects, probably by interfering with central dopaminergic neurotransmission. Expand
Receptor pharmacology.
  • A. Young
  • Medicine
  • Advances in pharmacology
  • 2005
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Comparative distribution of receptors for amylin and the related peptides calcitonin gene related peptide and calcitonin in rat and monkey brain.
The distribution of amylin receptors in brains of rat and monkey were mapped and compared with the distribution of receptors for calcitonin (CT) and calcitonIn gene related peptide (CGRP) and there was very little overlap with the pattern of CGRP receptor distribution. Expand
International Union of Pharmacology. XXXII. The Mammalian Calcitonin Gene-Related Peptides, Adrenomedullin, Amylin, and Calcitonin Receptors
A review of the calcitonin family of peptides aims to reconcile what is observed when the receptors are reconstituted in vitro with the properties they show in native cells and tissues. Expand
Identification of central projections from amylin-activated neurons to the lateral hypothalamus
Neuroanatomical evidence is provided that among the amylin activated areas, the LPB provides the strongest input to the dLHA, thus it may mediate theAmylin-induced inhibition of the d LHA. Expand
Inhibition of central amylin signaling increases food intake and body adiposity in rats.
The present results document significant increases of food intake and body adiposity resulting from inhibition of central amylin signaling, consistent with the hypothesis that CNS actions of endogenousAmylin contribute to the long-term regulation of energy balance. Expand