Antipsychotic-Induced Dopamine Supersensitivity Psychosis: Pharmacology, Criteria, and Therapy

  title={Antipsychotic-Induced Dopamine Supersensitivity Psychosis: Pharmacology, Criteria, and Therapy},
  author={G. Chouinard and Anne-No{\"e}l Samaha and V. Chouinard and Charles-Siegfried Peretti and N. Kanahara and Masayuki Takase and M. Iyo},
  journal={Psychotherapy and Psychosomatics},
  pages={189 - 219}
  • G. Chouinard, Anne-Noël Samaha, +4 authors M. Iyo
  • Published 2017
  • Medicine
  • Psychotherapy and Psychosomatics
  • The first-line treatment for psychotic disorders remains antipsychotic drugs with receptor antagonist properties at D2-like dopamine receptors. However, long-term administration of antipsychotics can upregulate D2 receptors and produce receptor supersensitivity manifested by behavioral supersensitivity to dopamine stimulation in animals, and movement disorders and supersensitivity psychosis (SP) in patients. Antipsychotic-induced SP was first described as the emergence of psychotic symptoms… CONTINUE READING
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