Antiprotozoal screening of 60 South African plants, and the identification of the antitrypanosomal germacranolides schkuhrin I and II.

@article{Mokoka2013AntiprotozoalSO,
  title={Antiprotozoal screening of 60 South African plants, and the identification of the antitrypanosomal germacranolides schkuhrin I and II.},
  author={T. Mokoka and Peter K Xolani and Stefanie Zimmermann and Y. Hata and M. Adams and M. Kaiser and N. Moodley and V. Maharaj and N. Koorbanally and M. Hamburger and R. Brun and G. Fouche},
  journal={Planta medica},
  year={2013},
  volume={79 14},
  pages={
          1380-4
        }
}
Two hundred and seven extracts were prepared from sixty plants from South Africa and screened for in vitro activity against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. For the 21 extracts which inhibited the growth of one or more parasites with more than 95 % at 10 µg/mL, the IC50 values against all four protozoal parasites and cytotoxic IC50 values against L6 myoblasts were determined. Amongst the most notable results are the activities of… Expand
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