Antiprotozoal activity of aporphine alkaloids isolated from Unonopsis buchtienii (Annonaceae).

@article{Waechter1999AntiprotozoalAO,
  title={Antiprotozoal activity of aporphine alkaloids isolated from Unonopsis buchtienii (Annonaceae).},
  author={A I Waechter and Angela Cave and Reynald Hocquemiller and Christian Bories and Viviana Mu{\~n}oz and Alain Fournet},
  journal={Phytotherapy research : PTR},
  year={1999},
  volume={13 2},
  pages={175-7}
}
On a preliminary screening, substantial leishmanicidal activity was observed for the petroleum ether and alkaloidal extracts of the stem bark of Unonopsis buchtienii, the alkaloids and sterols isolated from these were studied. Of the alkaloids, liriodenine exhibited the highest activity against Leishmania major and L donovani (IC100 = 3.12 micrograms/mL). On the other hand, O-methylmoschatoline and the petroleum ether extract without alkaloids showed an interesting in vitro activity against… CONTINUE READING
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