Antiproliferative terpenoids from almond hulls (Prunus dulcis): identification and structure-activity relationships.

@article{Amico2006AntiproliferativeTF,
  title={Antiproliferative terpenoids from almond hulls (Prunus dulcis): identification and structure-activity relationships.},
  author={Vincenzo Amico and Vincenza Barresi and Daniele Filippo Condorelli and Carmela Spatafora and Corrado Tringali},
  journal={Journal of agricultural and food chemistry},
  year={2006},
  volume={54 3},
  pages={810-4}
}
Bioassay-guided fractionation of the EtOAc crude extract from Sicilian almond hulls, a waste material from Prunus dulcis crop, allowed identification of 10 constituents, isolated as pure compounds (1-5, 7, and 10) or unseparable mixtures (5 + 6 and 8 + 9). All compounds were subjected to spectroscopic analysis and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide bioassay on MCF-7 human breast cancer cells. In addition to the main components oleanolic (1), ursolic (2), and betulinic… CONTINUE READING

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