Antiproliferative efficacy of angiotensin II receptor blockers in prostate cancer.

@article{Uemura2005AntiproliferativeEO,
  title={Antiproliferative efficacy of angiotensin II receptor blockers in prostate cancer.},
  author={Hiroji Uemura and Noboru Nakaigawa and Hitoshi Ishiguro and Yoshinobu Kubota},
  journal={Current cancer drug targets},
  year={2005},
  volume={5 5},
  pages={
          307-23
        }
}
An apparent low prevalence of cancer in hypertensive patients receiving angiotensin converting enzyme inhibitors is reported; however, the molecular mechanisms have not been elucidated. Angiotensin-II (Ang-II) is well known to be associated with hypertension, as a main peptide of the renin-angiotensin system, and its detailed molecular mechanisms have recently been elucidated. For instance, Ang-II directly activates the mitogenic signal transduction pathway through the angiotensin-II type-1… CONTINUE READING
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