Antiproliferative effects of interferon alpha on hepatic progenitor cells in vitro and in vivo.

@article{Lim2006AntiproliferativeEO,
  title={Antiproliferative effects of interferon alpha on hepatic progenitor cells in vitro and in vivo.},
  author={Rebecca Lim and Belinda Knight and Keyur A. Patel and John McHutchison and George C.T. Yeoh and John K Olynyk},
  journal={Hepatology},
  year={2006},
  volume={43 5},
  pages={1074-83}
}
Hepatic progenitor cells (called oval cells in rodents) proliferate during chronic liver injury. They have been suggested as targets of malignant transformation in chronic liver diseases, including chronic hepatitis C. Interferon alpha therapy reduces the risk of hepatocellular carcinoma (HCC) in chronic hepatitis C regardless of viral clearance. The aim of this study was to determine whether interferon alpha could reduce the risk of HCC by modifying preneoplastic events in the hepatic… CONTINUE READING

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