Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines

@article{Poli2005AntiproliferativeEO,
  title={Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines},
  author={F. Poli and G. Appendino and G. Sacchetti and M. Ballero and N. Maggiano and F. Ranelletti},
  journal={Phytotherapy Research},
  year={2005},
  volume={19}
}
Certain jaesekanadiol p‐hydroxy‐ and p‐methoxybenzoates – typical of Ferula communis and Ferula arrigonii sardinian plants – show antiproliferative activity on human colon cancer less. The inhibitory doses 50%, calculated after 72 h of treatment, revealed that the antiproliferative capacity of the compounds was in the following descending order: ferutinin > 2α‐OH‐ferutidin > ferutidin > siol anisate > lapiferin > jaeskeanadiol. Evidence is presented that interaction with type II estrogen… Expand
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The exclusively Old World genus Ferula belongs to the family Umbelliferae (tribe Peucedaneae, subtribe Peucedaninae) (1) with some 130 species distributed throughout the Mediterranean area andExpand
Daucane esters from Ferula arrigonii
Abstract F. arrigonii gave one C-10 hydroxylated and two C-2 oxygenated jaeskeanadiol esters. Sesquiterpene-coumarin ethers were also isolated. The relationship between F. communis and F. arrigoniiExpand
Oxygenated sesquiterpenoids from a nonpoisonous sardinian chemotype of giant fennel (Ferula communis).
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Despite the lack of morphological differences, a broad chemical diversity exists within giant fennel, underlying the contrasting data on its poisonous properties. Expand
A carotane sesquiterpene as a potent modulator of the Maxi-K channel from Arthrinium phaesospermum
Abstract A potent modulator of the Maxi-K channel, isolated from Arthrinium phaeospermum , has been determined to be a carotane sesquiterpene by spectroscopic means. X-ray crystallographic studiesExpand
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Q could regulate colon cancer cell growth through a binding interaction with type‐ll EBS, and this mechanism could also be active in vivo as it is observed that cytosolic type‐II EBS are present in primary colorectal cancers and that Q is effective in inhibiting the in vitro bromodeoxyuridine incorporated by neoplastic cells in these cancers. Expand
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Abstract The daucane/carotane class of sesquiterpenes is reviewed. Aspects of their chemistry, stereochemistry, spectroscopy and biogenesis are discussed. All the known daucanes are listed, togetherExpand
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The results suggesting that tamoxifen and quercetin can inhibit melanoma cell growth by interacting with type II estrogen binding sites help explain the reported effectiveness of tamoxIFen, particularly in estrogen-receptor-negative tumors, and stress the potential role of quercETin in the treatment of melanoma. Expand
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The results indicate that multidrug-resistant estrogen-receptor-negative MCF-7 cells express, type II EBSs and are sensitive to the inhibitory effect of Q, which could be the parent compound of a novel class of anticancer agents. Expand
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The data indicate that quercetin and tamoxifen could be potentially useful in laryngeal cancer treatment and the possibility exists that the action of these compounds is mediated, at least in part, by the interaction with Type II EBS. Expand
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Examination of levels of activity of methyl‐p‐hydroxyphenyl‐lactate esterase and cytosolic Type‐II‐estrogen‐binding sites in primary ovarian cancer found a statistically significant relationship was found between high MeHPLA‐ase activity and longer overall survival. Expand
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