Antiproliferative effects of crocin in HepG2 cells by telomerase inhibition and hTERT down-regulation.

@article{Noureini2012AntiproliferativeEO,
  title={Antiproliferative effects of crocin in HepG2 cells by telomerase inhibition and hTERT down-regulation.},
  author={Sakineh Kazemi Noureini and Michael Wink},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2012},
  volume={13 5},
  pages={2305-9}
}
Crocin, the main pigment of Crocus sativus L., has been shown to have antiproliferative effects on cancer cells, but the involved mechanisms are only poor understood. This study focused on probable effect of crocin on the immortality of hepatic cancer cells. Cytotoxicity of crocin (IC50 3 mg/ml) in hepatocarcinoma HepG2 cells was determined after 48 h by neutral red uptake assay and MTT test. Immortality was investigated through quantification of relative telomerase activity with a quantitative… CONTINUE READING
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