Antiproliferative effects of cannabinoid agonists on deep infiltrating endometriosis.

  title={Antiproliferative effects of cannabinoid agonists on deep infiltrating endometriosis.},
  author={Mahaut Leconte and Carole Nicco and Charlotte Ng{\^o} and Sylviane Arkwright and Christiane Ch{\'e}reau and Jean Guibourdenche and Bernard Weill and Charles Chapron and Bertrand Dousset and Fr{\'e}d{\'e}ric Batteux},
  journal={The American journal of pathology},
  volume={177 6},
Deep infiltrating endometriosis (DIE) is characterized by chronic pain, hyperproliferation of endometriotic cells and fibrosis. Since cannabinoids are endowed with antiproliferative and antifibrotic properties, in addition to their psychogenic and analgesic effects, cannabinoid agonists have been evaluated in DIE both in vitro and in vivo. The in vitro effects of the cannabinoid agonist WIN 55212-2 were evaluated on primary endometriotic and endometrial stromal and epithelial cell lines… CONTINUE READING


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