Antiproliferative effect of two novel COX-2 inhibitors on human keratinocytes.
@article{Sticozzi2013AntiproliferativeEO, title={Antiproliferative effect of two novel COX-2 inhibitors on human keratinocytes.}, author={Claudia Sticozzi and Giuseppe Belmonte and Franco Cervellati and Angela Di Capua and Emanuela Maioli and Andrea Cappelli and Antonio Giordani and Mariangela Biava and Maurizio Anzini and Giuseppe Valacchi}, journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences}, year={2013}, volume={49 2}, pages={ 133-41 } }
21 Citations
Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties.
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Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold.
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The effect of resveratrol and its methylthio-derivatives on NF-κB and AP-1 signaling pathways in HaCaT keratinocytes.
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Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity.
- Chemistry, BiologyEuropean journal of medicinal chemistry
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Selective inhibition of COX-2 improves cutaneous wound healing of pressure ulcers in mice through reduction of iNOS expression.
- MedicineLife sciences
- 2016
Anti-Psoriasis Effect of Diclofenac and Celecoxib Using the Tail Model for Psoriasis
- MedicinePharmaceutics
- 2022
Celecoxib 2% had the greatest percentual drug activity and is a promising substance for the anti-psoriasis topical treatment and along with the COX-2 inhibition, celecoxib might have an anti-PSoriasis effect by other independent mechanisms.
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- ChemistryChemistry of Heterocyclic Compounds
- 2017
This minireview surveys the work of our research group directed toward finding novel antimycobacterial and anti-inflammatory drugs. Many active compounds were found with a common 1,5-diarylpyrrole…
5‐hydroxytryptophan attenuates imiquimod‐induced psoriasiform dermatitis probably through inhibition of IL‐17A production and keratinocyte activation
- Biology, MedicineExperimental dermatology
- 2018
5(OH)Trp can inhibit imiquimod‐induced psoriasiform dermatitis in mice and inhibit activation in keratinocytes and splenocytes, and reduce the cumulative scores, epidermal thickness and ki‐67 expression in the skin.
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.
- Chemistry, BiologyBioorganic & medicinal chemistry
- 2013
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