Antiproliferative effect of the somatostatin analogue octreotide on growth hormone-producing pituitary tumors: results of a multicenter randomized trial.

@article{Thapar1997AntiproliferativeEO,
  title={Antiproliferative effect of the somatostatin analogue octreotide on growth hormone-producing pituitary tumors: results of a multicenter randomized trial.},
  author={Kamal Thapar and Kalman T. Kovacs and Lucia Stefaneanu and Bernd Walter Scheithauer and Eva Horv{\'a}th and Ricardo Vincent Lloyd and Jin-bao Li and Edward R. Laws},
  journal={Mayo Clinic proceedings},
  year={1997},
  volume={72 10},
  pages={893-900}
}
OBJECTIVE To determine and quantify the in vivo effects of octreotide on the cell cycle kinetics of growth hormone-producing pituitary adenomas. DESIGN A multicenter randomized trial had been conducted to assess the clinical efficacy of octreotide, and we studied tissue specimens from pituitary macroadenomas in 32 patients with acromegaly from that trial… CONTINUE READING