Antiproliferative effect of metformin on the endometrium--a clinical trial.

  title={Antiproliferative effect of metformin on the endometrium--a clinical trial.},
  author={Ali Dastranj Tabrizi and Manijeh Sayyah Melli and Meraj Foroughi and Morteza Ghojazadeh and Sanam Bidadi},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  volume={15 23},
BACKGROUND Unopposed estrogen has a central role in development of endometrial benign, premalignant and malignant lesions. The aim of this study was to evaluate the anti-estrogenic effect of metformin on endometrial histology in comparison with progesterone. MATERIALS AND METHODS A total of 43 patients who were referred to our center for abnormal uterine bleeding and had a histologic diagnosis were disordered proliferative endometrium or simple endometrial hyperplasia were included and… CONTINUE READING
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The incidence of endometrial hyperplasia and cancer in 1031 patients with a granulosa cell tumor of the ovary: long-term follow-up in a population-based cohort study

  • HS van Meurs, MC Bleeker, J van der Velden
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