Antiproliferative effect of interleukin-4 in B chronic lymphocytic leukemia.

  title={Antiproliferative effect of interleukin-4 in B chronic lymphocytic leukemia.},
  author={Hui Yan Luo and M. Luz Rubio and Guy Biron and Guy J. Delespesse and Marika Sarfati},
  journal={Journal of immunotherapy : official journal of the Society for Biological Therapy},
  volume={10 6},
Recombinant interleukin-4 (IL-4) profoundly inhibits the proliferative response of chronic lymphocytic leukemic B cells (B-CLLs) to recombinant interleukin-2 (IL-2). In the present study, we confirmed and extended these data by showing that IL-4 strongly suppresses the [3H]thymidine incorporation by B-CLLs stimulated by recombinant tumor necrosis factor alpha, recombinant interferon alpha, IL-2, and low molecular weight B cell growth factor in the absence of costimulant. Recombinant interleukin… CONTINUE READING