Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines

  title={Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines},
  author={Bogl{\'a}rka Csupor-L{\"o}ffler and Z. Hajd{\'u} and I. Zupk{\'o} and B. R{\'e}thy and G. Falkay and P. Forg{\'o} and J. Hohmann},
  journal={Phytotherapy Research},
The antiproliferative activities of n‐hexane, chloroform, aqueous‐methanol and aqueous extracts of the aerial parts of the Achillea millefolium aggregate on three human tumour cell lines were investigated by means of MTT assays. The chloroform‐soluble extract exerted high tumour cell proliferation inhibitory activities on HeLa and MCF‐7 cells, and a moderate effect on A431 cells; accordingly, it was subjected to detailed bioactivity‐guided fractionation. As a result of the multistep… Expand
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Achillea millefolium L. hydroethanolic extract inhibits growth of human tumor cell lines by interfering with cell cycle and inducing apoptosis.
The cell growth inhibitory activity of the hydroethanolic extract of Achillea millefolium was studied in human tumor cell lines and its mechanism of action was investigated, enhancing the importance of A. mille folium as source of bioactive phenolic compounds, particularly of XIAP inhibitors. Expand
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Achillea millefolium L. ethyl acetate fraction induces apoptosis and cell cycle arrest in human cervical cancer (HeLa) cells
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Modulation of the G2 cell cycle checkpoint by sesquiterpene lactones psilostachyins A and C isolated from the common ragweed Ambrosia artemisiifolia.
Assay-guided fractionation led to the identification of the sesquiterpene lactones psilostachyins A and C as novel checkpoint inhibitors, suggesting that the compounds can bind covalently to target proteins through Michael addition. Expand
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Examination of the aerial parts of Achillea clavennae afforded eight guaianolides, the most active was flavonol centaureidin (12), already known as cytotoxic compound, and five new compounds, which were determined by spectroscopic methods. Expand
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Structure-activity requirements for flavone cytotoxicity and binding to tubulin.
A series of 79 flavones related to centaureidin (3,6,4'-trimethoxy-5, 7,3'-trihydroxyflavone, 1) was screened for cytotoxicity in the NCI in vitro 60-cell line human tumor screen. The resultingExpand
Novel antitumor sesquiterpenoids in Achillea millefolium.
Three new antitumor sesquiterpenoids, achimillic acids A, B and C, were isolated as methyl esters from Achillea millefolium and their structures were determined spectroscopically. The compounds wereExpand
Cytotoxic activity of some natural and synthetic guaianolides.
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