Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines

@article{CsuporLffler2009AntiproliferativeEO,
  title={Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines},
  author={Bogl{\'a}rka Csupor-L{\"o}ffler and Z. Hajd{\'u} and I. Zupk{\'o} and B. R{\'e}thy and G. Falkay and P. Forg{\'o} and J. Hohmann},
  journal={Phytotherapy Research},
  year={2009},
  volume={23}
}
The antiproliferative activities of n‐hexane, chloroform, aqueous‐methanol and aqueous extracts of the aerial parts of the Achillea millefolium aggregate on three human tumour cell lines were investigated by means of MTT assays. The chloroform‐soluble extract exerted high tumour cell proliferation inhibitory activities on HeLa and MCF‐7 cells, and a moderate effect on A431 cells; accordingly, it was subjected to detailed bioactivity‐guided fractionation. As a result of the multistep… Expand
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TLDR
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Three new antitumor sesquiterpenoids, achimillic acids A, B and C, were isolated as methyl esters from Achillea millefolium and their structures were determined spectroscopically. The compounds wereExpand
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