Antiproliferative and differentiating effects of benzodiazepine receptor ligands on B16 melanoma cells.

@article{Landau1998AntiproliferativeAD,
  title={Antiproliferative and differentiating effects of benzodiazepine receptor ligands on B16 melanoma cells.},
  author={Marina Landau and Abraham Weizman and Esther Zoref-Shani and Einat Beery and L Wasseman and Ofer Landau and Moshe Gavish and Sebastian Brenner and Jardena Nordenberg},
  journal={Biochemical pharmacology},
  year={1998},
  volume={56 8},
  pages={1029-34}
}
In this study, we evaluated the effect of several ligands active at the central-type and peripheral-type benzodiazepine receptor (BzR) (clonazepam, diazepam, PK11195 and Ro5-4864) on the growth and differentiation of B16 melanoma cells. All tested BzR ligands were able to suppress proliferation of the cells at the micromolar range and in a concentration… CONTINUE READING