Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines.

  title={Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines.},
  author={Cristobal L. Miranda and J. Frederik Stevens and Angela Helmrich and Marilyn C. Henderson and Russell J. Rodriguez and Y H Yang and Max L. Deinzer and David Barnes and Donald Raymond Buhler},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  volume={37 4},
  • C. Miranda, J. F. Stevens, D. Buhler
  • Published 1 April 1999
  • Chemistry, Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines.
A comparison of the anticancer properties of isoxanthohumol and 8-prenylnaringenin using in vitro models of colon cancer.
It is demonstrated that both Ix and its gut microbial metabolite 8-PN exert anticancer effects on models of key stages of colon tumourigenesis.
Antiproliferative effects of prenylflavonoids from hops on human colon cancer cell lines
In recent years, interest in hop-derived constituents, especially for prenylflavonoids has grown, as they have a wide range of biological properties including antioxidant, anticarcinogenic and
Highly Cancer Selective Antiproliferative Activity of Natural Prenylated Flavonoids
It was found that tested chalcones possessed highly selective antiproliferative activity towards all tested breast cancer lines compared to the normal breast MCF 10A cell line (the calculated selectivity index ranged from 5 to 10).
Synthesis and biological evaluation of 4'-O-acetyl-isoxanthohumol and its analogues as antioxidant and antiproliferative agents.
Both acylated isoxanthohumols showed preferential activity against tumor cells (MCF-7) and low cytotoxicity to normal cells ( MCF-10A), which suggests selectivity of the acylate isox anthohumol towards cancer cells.
Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines
It is suggested that DXN and TXN could show promise as therapeutic agents against colorectal and liver cancer in preclinical studies without the drawback of metabolism into a phytoestrogen.
Cytotoxic Effect of Flavonoids from the Roots of Glycyrrhiza uralensis on Human Cancer Cell Lines
The roots of Glycyrrhiza uralensis Fisch. were extracted with 30% aqueous ethanol (EtOH), and the concentrated extract was partitioned with n-hexane, chloroform (CHCl3), ethyl acetate (EtOAc),
It can be concluded that X, IX, 8PN, and 6PN appear to be promising candidates for further investigation in prostate anticancer therapy and chemoprevention, especially in the final stages.


Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices.
Evidence of anticancer properties of orange juice and indicate that citrus flavonoids are effective inhibitors of human breast cancer cell proliferation in vitro are provided, especially when paired with quercetin, which is widely distributed in other foods.
Effect of synthetic and naturally occurring chalcones on ovarian cancer cell growth: structure-activity relationships.
The data indicate that chalcones could be considered as potential new anticancer drugs and structure-related variations in IC50 and Di50 were significantly concordant, suggesting that there may be a type II EBS-mediated mechanism for chalcone antiproliferative activity.
Inhibitory effects of 2-hydroxy chalcone and other flavonoids on human cancer cell-proliferation.
The effect of thirty-one flavonoids on monolayer HeLa cell proliferation was studied and their structure activity relationship was rationalised, indicating that the mode of action of 2-hydroxy chalcone and colchicine are different.
In vitro biotransformation of flavonoids by rat liver microsomes.
Sixteen naturally occurring flavonoids were investigated as substrates for cytochrome P450 in uninduced and Aroclor 1254-induced rat liver microsomes and results indicate that demethylation only occurs in the B-ring when the methoxy group is positioned at C4', and not at the C3'-position.
Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein.
Results indicate that flavonoids constitute a new class of modulators with bifunctional interactions at vicinal ATP-binding site and steroid-interacting region within a cytosolic domain of P-glycoprotein.
The structure-activity relationships of flavonoids as inhibitors of cytochrome P-450 enzymes in rat liver microsomes and the mutagenicity of 2-amino-3-methyl-imidazo[4,5-f]quinoline.
Results indicated that flavones or flavonols that contain C5, C7 and C4' hydroxyl groups are potent inhibitors of P-450 enzyme activities induced by Aroclor 1254, and may potentially be useful as chemopreventive agents against heterocyclic amine-induced mutagenesis or carcinogenesis.
Potent inhibition of breast cancer cell lines by the isoflavonoid kievitone: comparison with genistein.
  • R. Hoffman
  • Biology, Chemistry
    Biochemical and biophysical research communications
  • 1995
Genistein was about 5-fold more potent than kievitone as an inhibitor of solubilised epidermal growth factor (EGF) receptor kinase activity and EGF receptor autophosphorylation and was 3-9 fold weaker as an inhibitors of the proliferation of the breast cancer cell lines and of growth factor-stimulated DNA synthesis.