Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines.

@article{Miranda1999AntiproliferativeAC,
  title={Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines.},
  author={Cristobal L. Miranda and J. Frederik Stevens and Angela Helmrich and Marilyn C. Henderson and Russell J. Rodriguez and Y H Yang and Max L. Deinzer and David Barnes and Donald Raymond Buhler},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1999},
  volume={37 4},
  pages={
          271-85
        }
}
  • C. Miranda, J. F. Stevens, D. Buhler
  • Published 1 April 1999
  • Chemistry, Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines.
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TLDR
It is demonstrated that both Ix and its gut microbial metabolite 8-PN exert anticancer effects on models of key stages of colon tumourigenesis.
Antiproliferative effects of prenylflavonoids from hops on human colon cancer cell lines
In recent years, interest in hop-derived constituents, especially for prenylflavonoids has grown, as they have a wide range of biological properties including antioxidant, anticarcinogenic and
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TLDR
It was found that tested chalcones possessed highly selective antiproliferative activity towards all tested breast cancer lines compared to the normal breast MCF 10A cell line (the calculated selectivity index ranged from 5 to 10).
Synthesis and biological evaluation of 4'-O-acetyl-isoxanthohumol and its analogues as antioxidant and antiproliferative agents.
TLDR
Both acylated isoxanthohumols showed preferential activity against tumor cells (MCF-7) and low cytotoxicity to normal cells ( MCF-10A), which suggests selectivity of the acylate isox anthohumol towards cancer cells.
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TLDR
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Cytotoxic Effect of Flavonoids from the Roots of Glycyrrhiza uralensis on Human Cancer Cell Lines
The roots of Glycyrrhiza uralensis Fisch. were extracted with 30% aqueous ethanol (EtOH), and the concentrated extract was partitioned with n-hexane, chloroform (CHCl3), ethyl acetate (EtOAc),
BIOACTIVITIES OF HOP-DERIVED PRENYLFLAVONOIDS IN RELATION TO PROSTATE CANCER
TLDR
It can be concluded that X, IX, 8PN, and 6PN appear to be promising candidates for further investigation in prostate anticancer therapy and chemoprevention, especially in the final stages.
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