Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells.

Abstract

We evaluated whether inhibition of heat shock protein 90 (hsp90) function by novobiocin derivatives could induce the degradation of signal transducers that drive cancer cell growth and thereby promote apoptosis. Removal of the noviose moiety in novobiocin and introduction of a tosyl substituent at C-4 or C-7 coumarin nucleus provided derivatives 4TCNA and… (More)
DOI: 10.1016/j.canlet.2008.09.001

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@article{Radanyi2009AntiproliferativeAA, title={Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells.}, author={Christine Radanyi and Ga{\"{e}lle Le Bras and V{\'e}ronique Marsaud and Jean-François Peyrat and Samir Messaoudi and M Catelli and Jean-Daniel Brion and Mou{\^a}d Alami and J. Renoir}, journal={Cancer letters}, year={2009}, volume={274 1}, pages={88-94} }