Antiproliferative and antimigratory actions of synthetic long chain n-3 monounsaturated fatty acids in breast cancer cells that overexpress cyclooxygenase-2.

@article{Cui2012AntiproliferativeAA,
  title={Antiproliferative and antimigratory actions of synthetic long chain n-3 monounsaturated fatty acids in breast cancer cells that overexpress cyclooxygenase-2.},
  author={Pei H. Cui and Tristan Rawling and Kirsi Bourget and Terry Kim and Colin C. Duke and Munikumar Reddy Doddareddy and David E. Hibbs and Fanfan Zhou and Bruce N. Tattam and Nenad T. Petrovic and Michael Murray},
  journal={Journal of medicinal chemistry},
  year={2012},
  volume={55 16},
  pages={7163-72}
}
Cyclooxygenase-2 (COX-2) is overexpressed in many human cancers and converts the n-6 polyunsaturated fatty acid (PUFA) arachidonic acid to prostaglandin E(2) (PGE(2)), which drives tumorigenesis; in contrast, n-3 PUFA inhibit tumorigenesis. We tested the hypothesis that these antitumor actions of n-3 PUFA may involve the n-3 olefinic bond. n-3 Monounsaturated fatty acids (MUFAs) of chain length C16-C22 were synthesized and evaluated in MDA-MB-468 breast cancer cells that stably overexpressed… CONTINUE READING