Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells.

@article{Marrazzo2011AntiproliferativeAO,
  title={Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells.},
  author={Agostino Marrazzo and Jole Fiorito and Laura Zappal{\`a} and Orazio Prezzavento and Simone Ronsisvalle and Lorella Pasquinucci and Giovanna Maria Scoto and Renato Bernardini and Giuseppe Ronsisvalle},
  journal={European journal of medicinal chemistry},
  year={2011},
  volume={46 1},
  pages={
          433-8
        }
}
Complex mechanisms of prostate cancer progression prompt to novel therapeutic strategies concerning a combination of drugs or of single molecules able to interact with more crucial targets. Histone deacetylase inhibitors and sigma ligands with mixed σ(1) antagonist and σ(2) agonist properties were proposed as new potential tools for treatment of prostate cancer. (±)-MRJF4 was synthesized as phenylbutyrate ester of haloperidol metabolite II, which is a molecule consisting of a histone… CONTINUE READING
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